diff --git a/pyqtgraph/graphicsItems/PlotCurveItem.py b/pyqtgraph/graphicsItems/PlotCurveItem.py
index 2197a6cd..3d3e969d 100644
--- a/pyqtgraph/graphicsItems/PlotCurveItem.py
+++ b/pyqtgraph/graphicsItems/PlotCurveItem.py
@@ -173,8 +173,14 @@ class PlotCurveItem(GraphicsObject):
             if pxPad > 0:
                 # determine length of pixel in local x, y directions    
                 px, py = self.pixelVectors()
-                px = 0 if px is None else px.length()
-                py = 0 if py is None else py.length()
+                try:
+                    px = 0 if px is None else px.length()
+                except OverflowError:
+                    px = 0
+                try:
+                    py = 0 if py is None else py.length()
+                except OverflowError:
+                    py = 0
                 
                 # return bounds expanded by pixel size
                 px *= pxPad
diff --git a/pyqtgraph/graphicsItems/ROI.py b/pyqtgraph/graphicsItems/ROI.py
index 179dafdc..d51f75df 100644
--- a/pyqtgraph/graphicsItems/ROI.py
+++ b/pyqtgraph/graphicsItems/ROI.py
@@ -822,7 +822,10 @@ class ROI(GraphicsObject):
             if not self.rotateAllowed:
                 return
             ## If the handle is directly over its center point, we can't compute an angle.
-            if lp1.length() == 0 or lp0.length() == 0:
+            try:
+                if lp1.length() == 0 or lp0.length() == 0:
+                    return
+            except OverflowError:
                 return
             
             ## determine new rotation angle, constrained if necessary
@@ -862,7 +865,10 @@ class ROI(GraphicsObject):
             else:
                 scaleAxis = 0
             
-            if lp1.length() == 0 or lp0.length() == 0:
+            try:
+                if lp1.length() == 0 or lp0.length() == 0:
+                    return
+            except OverflowError:
                 return
             
             ang = newState['angle'] - lp0.angle(lp1)
diff --git a/pyqtgraph/graphicsItems/ScatterPlotItem.py b/pyqtgraph/graphicsItems/ScatterPlotItem.py
index 1c11fcf9..bdf89c45 100644
--- a/pyqtgraph/graphicsItems/ScatterPlotItem.py
+++ b/pyqtgraph/graphicsItems/ScatterPlotItem.py
@@ -664,8 +664,14 @@ class ScatterPlotItem(GraphicsObject):
         if pxPad > 0:
             # determine length of pixel in local x, y directions    
             px, py = self.pixelVectors()
-            px = 0 if px is None else px.length() 
-            py = 0 if py is None else py.length()
+            try:
+                px = 0 if px is None else px.length()
+            except OverflowError:
+                px = 0
+            try:
+                py = 0 if py is None else py.length()
+            except OverflowError:
+                py = 0
             
             # return bounds expanded by pixel size
             px *= pxPad