diff --git a/pyqtgraph/graphicsItems/ImageItem.py b/pyqtgraph/graphicsItems/ImageItem.py
index d1e4aa9e..5813fa8f 100644
--- a/pyqtgraph/graphicsItems/ImageItem.py
+++ b/pyqtgraph/graphicsItems/ImageItem.py
@@ -379,6 +379,10 @@ class ImageItem(GraphicsObject):
             image = fn.downsample(self.image, xds, axis=axes[0])
             image = fn.downsample(image, yds, axis=axes[1])
             self._lastDownsample = (xds, yds)
+            
+            # Check if downsampling reduced the image size to zero due to inf values.
+            if image.size == 0:
+                return
         else:
             image = self.image