diff --git a/pyqtgraph/tests/test_reload.py b/pyqtgraph/tests/test_reload.py
index 934d2ed2..11b12cf2 100644
--- a/pyqtgraph/tests/test_reload.py
+++ b/pyqtgraph/tests/test_reload.py
@@ -1,6 +1,7 @@
 import tempfile, os, sys, shutil, time
 import pyqtgraph as pg
 import pyqtgraph.reload
+import pytest
 
 
 pgpath = os.path.join(os.path.dirname(pg.__file__), '..')
@@ -41,7 +42,11 @@ def remove_cache(mod):
     if os.path.isdir(cachedir):
         shutil.rmtree(cachedir)
 
-
+@pytest.mark.skipif(
+    pg.Qt.QT_LIB == "PySide2"
+    and pg.Qt.PySide2.__version__.startswith("5.15")
+    and sys.version_info > (3, 9),
+    reason="Unknown Issue")
 def test_reload():
     py3 = sys.version_info >= (3,)