diff --git a/pyqtgraph/graphicsItems/ROI.py b/pyqtgraph/graphicsItems/ROI.py
index 7863dfef..43bb921d 100644
--- a/pyqtgraph/graphicsItems/ROI.py
+++ b/pyqtgraph/graphicsItems/ROI.py
@@ -758,6 +758,9 @@ class ROI(GraphicsObject):
             remAct.triggered.connect(self.removeClicked)
             self.menu.addAction(remAct)
             self.menu.remAct = remAct
+        # ROI menu may be requested when showing the handle context menu, so
+        # return the menu but disable it if the ROI isn't removable
+        self.menu.setEnabled(self.contextMenuEnabled())
         return self.menu
 
     def removeClicked(self):