diff --git a/.github/workflows/codeql-analysis.yml b/.github/workflows/codeql-analysis.yml
index 05b85ca5..0974fe1f 100644
--- a/.github/workflows/codeql-analysis.yml
+++ b/.github/workflows/codeql-analysis.yml
@@ -20,7 +20,7 @@ jobs:
     - name: Install Dependencies
       run: |
         python -m pip install --upgrade pip
-        pip install PyQt5 numpy scipy six
+        pip install PyQt5 numpy scipy
         echo "CODEQL_PYTHON=$(which python)" >> $GITHUB_ENV
     
     # Initializes the CodeQL tools for scanning.
diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml
index ea6046a3..781aeebb 100644
--- a/.github/workflows/main.yml
+++ b/.github/workflows/main.yml
@@ -70,7 +70,7 @@ jobs:
     - name: Install Dependencies
       run: |
         pip install --upgrade pip
-        pip install ${{ matrix.qt-version }} numpy${{ matrix.numpy-version }} scipy pyopengl h5py six matplotlib
+        pip install ${{ matrix.qt-version }} numpy${{ matrix.numpy-version }} scipy pyopengl h5py matplotlib
         pip install .
         pip install pytest pytest-cov pytest-xdist coverage
     - name: "Install Linux VirtualDisplay"
diff --git a/pyqtgraph/tests/test_exit_crash.py b/pyqtgraph/tests/test_exit_crash.py
index 41703ce6..e5661386 100644
--- a/pyqtgraph/tests/test_exit_crash.py
+++ b/pyqtgraph/tests/test_exit_crash.py
@@ -4,7 +4,6 @@ import sys
 import subprocess
 import tempfile
 import pyqtgraph as pg
-import six
 import pytest
 import textwrap
 import time
diff --git a/pyqtgraph/tests/test_ref_cycles.py b/pyqtgraph/tests/test_ref_cycles.py
index 9819790b..905173c9 100644
--- a/pyqtgraph/tests/test_ref_cycles.py
+++ b/pyqtgraph/tests/test_ref_cycles.py
@@ -6,7 +6,6 @@ Test for unwanted reference cycles
 import pyqtgraph as pg
 import numpy as np
 import gc, weakref
-import six
 import pytest
 app = pg.mkQApp()
 
diff --git a/tox.ini b/tox.ini
index bc2c5403..c05fe689 100644
--- a/tox.ini
+++ b/tox.ini
@@ -16,7 +16,6 @@ deps =
     scipy
     pyopengl
     flake8
-    six
     coverage
 
 [testenv]