diff --git a/pyqtgraph/graphicsItems/ImageItem.py b/pyqtgraph/graphicsItems/ImageItem.py
index 5813fa8f..6017fabc 100644
--- a/pyqtgraph/graphicsItems/ImageItem.py
+++ b/pyqtgraph/graphicsItems/ImageItem.py
@@ -469,11 +469,11 @@ class ImageItem(GraphicsObject):
         
         This method is also used when automatically computing levels.
         """
-        if self.image is None:
+        if self.image is None or self.image.size == 0:
             return None,None
         if step == 'auto':
-            step = (int(np.ceil(self.image.shape[0] / targetImageSize)),
-                    int(np.ceil(self.image.shape[1] / targetImageSize)))
+            step = (max(1, int(np.ceil(self.image.shape[0] / targetImageSize))),
+                    max(1, int(np.ceil(self.image.shape[1] / targetImageSize))))
         if np.isscalar(step):
             step = (step, step)
         stepData = self.image[::step[0], ::step[1]]
diff --git a/pyqtgraph/imageview/ImageView.py b/pyqtgraph/imageview/ImageView.py
index c64953de..1d38a6c3 100644
--- a/pyqtgraph/imageview/ImageView.py
+++ b/pyqtgraph/imageview/ImageView.py
@@ -633,8 +633,12 @@ class ImageView(QtGui.QWidget):
             
         cax = self.axes['c']
         if cax is None:
+            if data.size == 0:
+                return [(0, 0)]
             return [(float(nanmin(data)), float(nanmax(data)))]
         else:
+            if data.size == 0:
+                return [(0, 0)] * data.shape[-1]
             return [(float(nanmin(data.take(i, axis=cax))), 
                      float(nanmax(data.take(i, axis=cax)))) for i in range(data.shape[-1])]