diff --git a/pyqtgraph/Qt.py b/pyqtgraph/Qt.py
index 4c2e4502..6dd05468 100644
--- a/pyqtgraph/Qt.py
+++ b/pyqtgraph/Qt.py
@@ -376,6 +376,15 @@ if QT_LIB == PYQT6:
         QtCore.QEvent.type = new_method
         del new_method
 
+    # PyQt6 6.1 renames some enums and flags to be in line with the other bindings.
+    # "Alignment" and "Orientations" are PyQt6 6.0 and are used in the generated
+    # ui files. Pending a regeneration of the template files, which would mean a
+    # drop in support for PyQt6 6.0, provide the old names for PyQt6 6.1.
+    # This is strictly a temporary private shim. Do not depend on it in your code.
+    if hasattr(QtCore.Qt, 'AlignmentFlag') and not hasattr(QtCore.Qt, 'Alignment'):
+        QtCore.Qt.Alignment = QtCore.Qt.AlignmentFlag
+    if hasattr(QtCore.Qt, 'Orientation') and not hasattr(QtCore.Qt, 'Orientations'):
+        QtCore.Qt.Orientations = QtCore.Qt.Orientation
 
 # USE_XXX variables are deprecated
 USE_PYSIDE = QT_LIB == PYSIDE
diff --git a/pyqtgraph/graphicsItems/ROI.py b/pyqtgraph/graphicsItems/ROI.py
index 73a686af..2dcbc759 100644
--- a/pyqtgraph/graphicsItems/ROI.py
+++ b/pyqtgraph/graphicsItems/ROI.py
@@ -826,10 +826,17 @@ class ROI(GraphicsObject):
         """
         return True
 
-    def movePoint(self, handle, pos, modifiers=QtCore.Qt.KeyboardModifiers(0), finish=True, coords='parent'):
+    def movePoint(self, handle, pos, modifiers=None, finish=True, coords='parent'):
         ## called by Handles when they are moved. 
         ## pos is the new position of the handle in scene coords, as requested by the handle.
-        
+        if modifiers is None:
+            try:
+                # this works for PyQt6 6.1 and other bindings
+                modifiers = QtCore.Qt.KeyboardModifier.NoModifier
+            except AttributeError:
+                # this works for PyQt6 6.0 and other bindings
+                modifiers = QtCore.Qt.KeyboardModifiers(0)
+
         newState = self.stateCopy()
         index = self.indexOfHandle(handle)
         h = self.handles[index]
@@ -1454,7 +1461,14 @@ class Handle(UIGraphicsItem):
             self.currentPen = self.hoverPen
             self.movePoint(pos, ev.modifiers(), finish=False)
 
-    def movePoint(self, pos, modifiers=QtCore.Qt.KeyboardModifiers(0), finish=True):
+    def movePoint(self, pos, modifiers=None, finish=True):
+        if modifiers is None:
+            try:
+                # this works for PyQt6 6.1 and other bindings
+                modifiers = QtCore.Qt.KeyboardModifier.NoModifier
+            except AttributeError:
+                # this works for PyQt6 6.0 and other bindings
+                modifiers = QtCore.Qt.KeyboardModifiers(0)
         for r in self.rois:
             if not r.checkPointMove(self, pos, modifiers):
                 return
diff --git a/pyqtgraph/widgets/RemoteGraphicsView.py b/pyqtgraph/widgets/RemoteGraphicsView.py
index c9549c8a..f486b2f9 100644
--- a/pyqtgraph/widgets/RemoteGraphicsView.py
+++ b/pyqtgraph/widgets/RemoteGraphicsView.py
@@ -259,9 +259,10 @@ class Renderer(GraphicsView):
 
     def deserialize_wheel_event(self, wheel_event):
         pos, gpos, pixelDelta, angleDelta, btns, mods, phase, inverted = wheel_event
-        btns = QtCore.Qt.MouseButtons(btns)
-        mods = QtCore.Qt.KeyboardModifiers(mods)
-        phase = QtCore.Qt.ScrollPhase(phase)
+        if QT_LIB != 'PyQt6':
+            btns = QtCore.Qt.MouseButtons(btns)
+            mods = QtCore.Qt.KeyboardModifiers(mods)
+            phase = QtCore.Qt.ScrollPhase(phase)
         return QtGui.QWheelEvent(pos, gpos, pixelDelta, angleDelta, btns, mods, phase, inverted)
 
     def mousePressEvent(self, mouse_event):