diff --git a/pyqtgraph/graphicsItems/ScatterPlotItem.py b/pyqtgraph/graphicsItems/ScatterPlotItem.py
index e5bb0d31..9759e3ae 100644
--- a/pyqtgraph/graphicsItems/ScatterPlotItem.py
+++ b/pyqtgraph/graphicsItems/ScatterPlotItem.py
@@ -649,6 +649,9 @@ class ScatterPlotItem(GraphicsObject):
             d = d[mask]
             d2 = d2[mask]
 
+            if d.size == 0:
+                return (None, None)
+
         if frac >= 1.0:
             self.bounds[ax] = (np.nanmin(d) - self._maxSpotWidth*0.7072, np.nanmax(d) + self._maxSpotWidth*0.7072)
             return self.bounds[ax]